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Linares LK et al (2003) HdmX stimulates Hdm2-mediated ubiquitination and degradation ofp53. (1962) Diffuse intracytoplasmicganglionic inclusions (Lewy type) associated with progressivedementia and quadriparesis in fl exion. (2003) Mild Cognitive Impairment: Aging to Alzheimer’sDisease. Eventually, these cells will return to normal in termsof their ability to respond to TCR stimulation and secrete and respond to IL-2.
Prolonged exposure of p53 knock-out and wild typemice to a hypoxic environment (8 weeks in 10 % oxygen) results not only in differ-ences in HIF1? and VEGF expression, but also physiological changes such as thick-ened blood vessels [ 36].
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